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KMID : 0438520060130010176
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Journal of the Korean Society of Neonatology
2006 Volume.13 No. 1 p.176 ~ p.179
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Hyponatremia and Generalized Edema Associated with Ibuprofen Therapy in a Neonate
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Kim So-Hee
Kim Eun-Young
Park Sang-Kee
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Abstract
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Ibuprofen is a nonsteroidal anti-inflammatory, analgesic, and antipyretic agent which has used for the treatment of rheumatoid and musculoskeletal disorders. Its side effects have generally been minor; these include dyspepsia, anorexia, nausea and vomiting, constipation, rashes, dizziness, and tinnitus. Ibuprofen is a prostaglandin synthetase inhibitor that is not recommended for neonates. It is pharmacologically similar to indomethacin, which is used to treat symptomatic patent ductus arteriosus in premature infants. We report here a case of a term infant who developed severe hyponatremia and generalized edema associated with the ingestion of an overdose of ibuprofen. The baby made a complete recovery. (J Korean Soc Neonatol 2006;13:176-179)
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KEYWORD
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Ibuprofen, Hyponatremia, Generalized edema, Neonate
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